Cabotegravir (GSK744, GSK1265744)

Name	Cabotegravir
Synonyms	GSK744 GSK1265744 Cabotegravir SK744, GSK1265744 Cyclic pyranopterin Cabotegravir Free Acid Cabotegravir (GSK744, GSK1265744) (3S,11aR)-N-[(2,4-Difluorophenyl)methyl]-2,3,5,7,11,11a-hexahydro-6-hydroxy-3-methyl-5,7-dioxo-oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide
CAS	1051375-10-0

Molecular Formula	C19H17F2N3O5
Molar Mass	405.35
Density	1.57±0.1 g/cm3(Predicted)
Boling Point	664.0±55.0 °C(Predicted)
Solubility	DMSO: 12.67 mg/mL
pKa	4.50±1.00(Predicted)
Storage Condition	-20℃
In vitro study	GSK1265744 inhibitors HIV replication with EC50 of 0.22 nM and 0.34-1.3 nM against St HIV-1 Ba-L and NL432, review. GSK1265744 produce cytotoxicity with CC50 of 6.4, 5.0, 9.2, and 13 μm in proliferating IM-9, U-937, MT-4, and Molt-4 cell lines, review. GSK1265744 inhibits HIV replication with EC50 of 0.22 nM and 0.34-1.3 nM for HIV-1 and NL432, respectively. GSK1265744 produced cytotoxicity in the proliferating IM-9,U-937,MT-4, and Molt-4 cell lines with CC50 of 6.4,5.0,9.2, and 13 μm, respectively.
In vivo study	GSK1265744 (50 mg/kg) treatment of proteins rhesus macahydrate against three high-dose SHIV challenges. GSK1265744 (50 mg/kg) prevented infection of rhesus monkeys with three high doses.

Last Update：2024-01-02 23:10:35

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Product Name: Cabotegravir Request for quotation
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052

Wechat: 15671228036

Spot supply

Product Name: Cabotegravir Visit Supplier Webpage Request for quotation
CAS: 1051375-10-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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Cabotegravir (GSK744, GSK1265744)

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